Pharmacokinetic In Vitro Assays - China

Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody.

The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster.

Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai Government.

Available studies include:

Method development and validation (GLP & Non-GLP)

Bioanalysis

Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration )

Stability in vehicles and plasma

Drug interaction studies

In vitro metabolic stability

Prediction and identification of major metabolites

Toxicokinetics analysis

Distribution studies

Pharmacokinetics Package for IND Filing

DMPK package for CFDA and FDA IND filing

Chemical Compounds

Traditional Chinese Medicine

Protein

Antibody

Metabolic Stability Services

CYP Reaction Phenotyping

Microsomal Stability

S9 Stability

Hepatocyte Stability

Plasma Stability

Metabolite Profiling & Identification

Drug-Drug Interaction Services

Cytochrome P450 and UGT Reaction Phenotyping

Hepatocyte Induction

Cytochrome P450 Inhibition

Time Dependent Inhibition (Single Point)

Permeability and Transporter Services

Caco-2 Permeability

P-gp Inhibition

Available reaction phenotyping services include:

Phase I:

Cytochrome P450 Enzymes (CYP)

Phase II:

UDP-glucuronyltransferase s (UGT)

Metabolic Stability

Microsomes stability

Hepatocytes stability

Plasma stability

S9 stability

Protein Binding Services

Plasma Protein Binding

Brain Tissue Binding

Whole Blood Binding

Blood to Plasma Ratio

Company Contact:

• Posted By: Shanghai Medicilon Inc.

• Phone: +862158591500

• Address: 585 Chuanda Road,Pudong,Shanghai20129 9,China, Shanghai , Pudong New Area, China

• Email:

• Website: https://www.medicilon.com

• Business Description: Medicilon offers fully integrated pharmaceutical services for the global scientific community.
  
  We focus on providing an exceptional client-centered experience and advancing the drug discovery process.
  
  Since the founding of our company in 2004, our integrated services across biology, chemistry and preclinical services are uniquely designed to help clients developing their research and discovery programs from the initial idea stage to the IND filing phase.