Resveratrol Grape Skin Extract - China

Resveratrol-Grape Skin Extract, CAS No.

501-36-0 Active

Iredient: Trans-Resveratrol Specification: 50% 98% 99% Test

Method HPLC Molecular formula: C14H12O3 Molecular weight:

228.24 CAS No: 501-36-0 Melt Point: 253℃～257T 51;

Solubility: Poor solubility in water, soluble in aether, chloroform,

ethanol, acetic acid and acetone.

Appearance: Fine crystal powder

Color: White Specific Rotation [α]: -77.5° (c=0.2, EtOH) Molecular

structure: What is resveratrol: Resveratrol (trans-3, 5, 4'-

trihydroxystilbene), belongs to a class of polyphenolic compounds

called stilbenes , found largely in the skins of red grapes and root of

Polygonum cuspidatum Sieb.

et Zucc ( Japanese knotweed), is a component

of Ko-jo-kon, an oriental medicine used to treat diseases of the blood

vessels, heart and live.

Resveratrol is a fat-soluble compound that

occurs in a trans and a cis configuration (see figure 1).

Both cis- and

trans-resveratrol also occur as glucosides (bound to a glucose

molecule).

Resveratrol-3-O-beta-gluc oside is also called piceid.

Sources While present in other plants, such as eucalyptus, spruce, and

lily, and in other foods such as mulberries and peanuts, resveratrol's

most abundant natural sources are Vitis vinifera, labrusca, and

muscadine grapes, Polygonum cuspidatum Sieb.

Cardiovascular Effects

Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD).

Several studies have demonstrated that resveratrol is an effective antioxidant.

It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation.

It is thought that because it contains highly hydrophilic and lipophilic properties, it can provide more effective protection than other well-known antioxidants, such as vitamins C and E.

On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine.

Reduced platelet aggregation has also been demonstrated in studies on resveratrol, further contributing to its prevention of atherosclerosis.

To date, most of the research on resveratrol's antioxidant and anti-platelet properties has been done in vitro (in an artificial environment using test-tube or tissue-culture preparations).

Further studies in animals and humans are necessary to determine whether resveratrol supplementation makes sense.

Cancer-Related Effects

Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer.

With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation, and as an anti-mutagen in rat models.

Resveratrol appears to decrease tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1), an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth .

Studies related to progression have found that resveratrol induced human promyelocytic leukemia cell differentiation and inhibited ribonucleotide reductase, an enzyme needed for DNA synthesis in proliferating cells .

One appealing characteristic of resveratrol's anti-cancer potential is its minimal toxicity to blood-forming cells .

More studies using both cellular and animal models are needed before any such data would be applicable to human use.

Resveratrol Grape Skin Extract

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Company Contact:

• Posted By: Changsha Organic Herb Inc

• Phone: 8673182739236

• Address: A301 International Enterprice Center, No. 188, Hua, Hunan , China

• Email:

• Website: http://www.organic-herb.com

• Business Description: Organic Herb Inc.
  
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