Anti Egfr E746 A750 Del Mouse Monoclonal Antibody - USA
price: contact company for price
Catalog Number: 26235
Gene Symbol: EGFR/ HER1/ ERBB1
Description: Anti- EGFR ( E746- A750) del Mouse Monoclonal Antibody
Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
It activates at least 4 major downstream signaling cascades including the RAS- RAF- MEK- ERK, PI3 kinase- AKT, PLCgamma- PKC and STATs modules.
Defects in EGFR are associated with lung cancer ( LNCR) .
Immunogen: A synthetic peptide from the internal region of EGFR which includes the deletion of E746- A750, human origin.
Applications: ELISA, WB
Recommended Dilutions:
ELISA: 1: 1000- 1: 5000
WB: 1: 500- 1: 1000
Concentration: 1 mg/ ml
Host: Mouse
Format: Liquid
Clonality: Monoclonal
Isotype:
Purity: Purified from ascites
Storage buffer:
Preservative: no
Constituents: PBS ( without Mg2+ and Ca2+) , pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes EGFR ( E746- A750) , but not wild type EGFR of vertebrates.
Storage Conditions: Store at - 20°C.
Avoid freeze / thaw cycles
Company Contact:
- Posted By: NewEast Biosciences
- Phone: 6109452007
- Address: 24 Whitewoods Lane, Malvern , PA , USA
- Email:
- Website: http://www.neweastbio.com
Published date: May 4, 2016
- Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins).
These unique antibodies do not recognize the inactive (GDP bound) G proteins.
These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections.
Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.
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