Npc2 Antibody Biotin Conjugated - China

Product Name:

NPC2 Antibody;Biotin conjugated

Code : CSB-PA015976LD01HU

Size : US$166

Uniprot NO.

: P61916

Storage : Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C.

Avoid repeated freeze.

Immunogen : Recombinant human Epididymal secretory protein E1 protein

Raised in : Rabbit

Species Reactivity : Human

Tested Applications : ELISA;Not yet tested in other applications.

Relevance : Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment.

Both NPC1 and NPC2 function as the cellular \'tag team duo\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE.

NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1 - Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism.

The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Form : Liquid

Conjugate : Biotin

Storage Buffer : Preservative: 0.03% Proclin 300

Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Isotype : IgG

Clonality : Polyclonal

Alias : Epididymal secretory protein E1, NPC2, HE1, Human epididymis-specific protein 1, He1, Niemann-Pick disease type C2 protein

Company Contact:

• Posted By: Cusabio Biotech Co., Ltd

• Phone: 862787582341

• Address: Building B11, #818 Gaoxin Road, Wuhan , China

• Email:

• Website: https://www.cusabio.com

• Business Description: CUSABIO is a leading biotechnology company specialized in production of
  
  high quality products for gene, protein, antibody, ELISA kit, raw
  
  material for production of diagnostic kit, drug residues, food safety
  
  small molecules & other small molecules.