Medical Biodegradable Ploymer Poly L Lactide Co Glycolide - China

Name : Poly(L-lactide-co-glycoli de)

Product Model : PLG

Chemical Formula: (C6H8O4)m (C4H4O4)n

CAS : 30846-39 -0

Chemical Structure :

Instructions: The alternate name of poly(L-lactide-co-

glycolide) (PLGA), is polylactic acid-glycollic acid

copolymer.

PLGA is produced from lactic acid and glycolic

acid.

It is non-toxic and has excellent biodegradability,

biocompatibility, film or capsule forming ability.

PLGA is

widely used in pharmaceutical, medical engineering materials

and modern industrial fields.

In the United States, PLGA has

been approved by the FDA and is formally included in the

United States pharmacopoeia as pharmaceutical materials.

PLGA is a amorphous polymer.

The glass transition

temperature (Tg) of PLGA is 40 - 60 °C.

It has been widely

used in medical surgical sutures, anti-adhesion membrane,

tissue engineering scaffolds and so on.

The degradation rate

of PLGA increases with the increase of GA proportion.

Different types of PLGA can be produced using

differentmonomer ratio .

For example, PLGA 75: 25 indicates

that the polymer consists of 75% lactic acid and 25%

glycolic acid.

The degradation products of PLGA are lactic acid and

glycolic acid, so they do not have toxic side effects when

used as the pharmaceutical and biological materials.

PLGA

has been widely used in biomedical fields, such as medical

anti-adhesion membrane, skin graft, stitched wound,

injectable microcapsules, microspheres, implants, scaffolds

for tissue engineering.

Appearance : White pale yellow powder or particles

L- lactide / Glycolic (mol/mol) : 90/10, 80/20, 75/25,

70/30, 50/50

IV (Intrinsic viscosity): 0.2-1.8 dL/g

Specific Rotation( ，chloroform): ≤ -50°

Glass Transition Temperature : 40-60°C

Melting point : Amorphous

Residual Monomers : < 1%

Residual Solvents : < 0.05%

Extractable Heavy Metals : <10 ppm

Stannum (Catalyst) : < 200 ppm

Density : 1.25 g/cm3

Sulfate Ash : < 0.05%

Model

Model Ratio LA/GA IV LA/GA Proportional Range

IV Range

dL/g

PLG90-03 90/10 0.3 87/13-93/7 0.20-0.40

PLG90-05 90/10 0.5 87/13-93/7 0.40-0.70

PLG90-08 90/10 0.8 87/13-93/7 0.70-1.00

PLG90-12 90/10 1.2 87/13-93/7 1.00-1.40

PLG90-16 90/10 1.6 87/13-93/7 1.40-1.80

PLG90-20 90/10 2.0 87/13-93/7 >1.80

PLG80-03 80/20 0.3 77/23-83/17 0.20-0.40

PLG80-05 80/20 0.5 77/23-83/17 0.40-0.70

PLG80-08 80/20 0.8 77/23-83/17 0.70-1.00

PLG80-12 80/20 1.2 77/23-83/17 1.00-1.40

PLG80-16 80/20 1.6 77/23-83/17 1.40-1.80

PLG80-20 80/20 2.0 77/23-83/17 >1.80

PLG75-03 75/25 0.3 72/28-78/22 0.20-0.40

PLG75-05 75/25 0.5 72/28-78/22 0.40-0.70

PLG75-08 75/25 0.8 72/28-78/22 0.70-1.00

PLG75-12 75/25 1.2 72/28-78/22 1.00-1.40

PLG75-16 75/25 1.6 72/28-78/22 1.40-1.80

PLG75-20 75/25 2.0 72/28-78/22 >1.80

PLG70-03 70/30 0.3 67/33-73/27 0.20-0.40

PLG70-05 70/30 0.5 67/33-73/27 0.40-0.70

PLG70-08 70/30 0.8 67/33-73/27 0.70-1.00

PLG70-12 70/30 1.2 67/33-73/27 1.00-1.40

PLG70-16 70/30 1.6 67/33-73/27 1.40-1.80

PLG70-20 70/30 2.0 67/33-73/27 >1.80

PLG50-03 50/50 0.3 47/53-53/47 0.20-0.40

PLG50-05 50/50 0.5 47/53-53/47 0.40-0.70

PLG50-08 50/50 0.8 47/53-53/47 0.70-1.00

PLG50-12 50/50 1.2 47/53-53/47 1.00-1.40

PLG50-16 50/50 1.6 47/53-53/47 1.40-1.80

PLG50-20 50/50 2.0 47/53-53/47 >1.80

Company Contact:

• Posted By: Changchun Sinobiomaterials Co.,Ltd.

• Phone: 15848782739

• Address: No. 666A Chaoqun Street, High-tech Industrial Deve, JILIN , China

• Email:

• Website: https://www.sinobiom.com

• Business Description: Changchun SinoBiomaterials Co., Ltd was founded in April 2007, High Tech
  
  Enterprises.
  
  It is mainly engaged in the manufacture of biodegradable
  
  polymer materials for medical applications, as well as the development
  
  and industrialization of the downstream products, such as L lactide (L
  
  LA), glycolic acid (GA), poly(L lactic acid) (PLLA), poly(glycolic acid)
  
  (PGA), poly(ε caprolactone) (PCL), monomethoxyl poly(ethylene glycol) b
  
  poly(lactic acid)(mPEG PLA) , Poly(D, L lactide) (PDLLA) and their
  
  copolymers, as well as absorbable internal fixation devices for fracture
  
  including bone screws and bone plates, tissue engineering scaffolds for
  
  bone repair, materials for sustained drug delivery, etc.
  
  Our company occupies an area of 10, 000 meter square with a total investment of 33.55 million yuan.
  
  There are an integrated experimental building and a production workshop in accordance with GMP standards, both occupying 3, 500 meter square.
  
  Over 90% of the employees in our company hold college degrees.
  
  The main management staffs have studied aboard for years.
  
  They have profound scientific attainments and abundant experience of management.
  
  With their expertise in chemical, biological and medical fields, our main technical staffs have strong capability for innovation and development of relative products.
  
  Changchun SinoBiomaterials Co., Ltd is technically supported by Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences.
  
  The Science and Technology Innovation Centre for poly(lactic acid) based biodegradable materials of Jilin Province and the Science and Technology Innovation Centre for poly(lactic acid) based biomaterials of Changchun City were founded jointly by SinoBiom and CIAC in 2007 and 2009, respectively.
  
  The foundation of these two research centres has been promoting the application of Medical biodegradable polymer materials in the medicine field and continuing to promote the pace of industrialization, with the goal of achieving the integration of production and studying and research.