M Bromophenylacrylic Acid - China

General description

3-Bromocinnamic acid is the metabolite of cinromide (3-bromo-N-ethylcinnamami de) and can be analysed in plasma by high-performance liquid chromatographic method.

Simultaneous determination of the anticonvulsants, cinromide (3-bromo-n-ethylcinnamami de), 3-bromocinnamamide, and carbamazepine in plasma by high-performance liquid chromatography.

3-Bromocinnamic acid is used as organic synthesis of raw materials, fine chemicals, pharmaceutical intermediates.

Abstract

A high-performance liquid chromatographic method is described for monitoring plasma concentrations of cinromide (3-bromo-N-ethylcinnamami de) and its de-ethylated metabolite.

Carbamazepine levels can be easily measured by the same technique.

The N-isopropyl analogue of cinromide is used as internal standard, and all compounds are easily separated on a reversed-phase column operated at 55 degrees with a small-diameter pre-column maintained at the same temperature.

The extraction is rapid and generally applicable to plasma and urine samples that are to be analyzed by reversed-phase chromatography.

Short- and long-term reproducibility studies show less than 4% relative standard deviation for replicate determinations for all drugs.

Limits of quantitation are 10-20 ng/ml with an internal standard concentration of 3 micrograms/ml.

Another metabolite of cinromide, 3-bromocinnamic acid, which may have some anticonvulsant effect, can be analyzed simultaneously by buffering the mobile phase and adding an ion-pairing reagent.

Storage: Pay attention to the source of fire, especially to avoid sunlight, and store in a cool place.

Company Contact:

• Posted By: Wuhan LANDMARK Industrial Co., Ltd.

• Phone: 02783916065

• Address: Jiang'an District of Wuhan, Wuhan , Hubei , China

• Email:

• Website: https://www.landmarkind.com

• Business Description: The company's main products are: cinnamic acid, cinnamaldehyde, cinnamon alcohol, methyl cinnamate, ethyl cinnamate, benzaldehyde and so on.
  
  The company has passed ISO9001 quality management system certification, and relying on the concept of independent development and joint development of universities, it has in-depth cooperation with major universities and scientific research institutions in Wuhan.
  
  It has successively obtained excellent companies with integrity standards, top ten outstanding private enterprises, and corporate credit evaluation AAA.
  
  Grade credit companies, etc.