Anti Egfr G719s Mouse Monoclonal Antibody - USA

Catalog Number: 26083

Gene Symbol: EGFR

Description: Anti-EGFR(G719S) Mouse Monoclonal Antibody

Background: EGFR is a receptor tyrosine kinase for ligands of the EGF family.

EGFR activates several signaling cascades to convert extracellular cues into appropriate cellular responses.

Defects in EGFR are associated with cancers such as lung cancer.

Immunogen: A synthetic peptide from the internal region of human EGFR which includes the mutation of G719S.

Applications: ELISA, WB, IHC, IF

Recommended Dilutions:

ELISA: 1: 1000-1: 5000

WB: 1: 1000-1: 2000

IHC: 1: 50-1: 1000

IF: 1: 50-1: 100

Concentration: 1 mg/ml

Host: mouse

Format: Liquid

Clonality: Monoclonal

Isotype: IgG

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes EGFR(G719S), but not wild type EGFR protein of vertebrates.

Storage Conditions: Store at -20°C.

Avoid freeze / thaw cycles.

Company Contact:

• Posted By: NewEast Biosciences

• Phone: 6109452007

• Address: 24 Whitewoods Lane, Malvern , PA , USA

• Email:

• Website: http://www.neweastbio.com

• Business Description: NewEast Biosciences are specialized in generating protein configuration specific monoclonal antibodies that recognize active (GTP bound) G proteins (including Ras superfamily small GTPases and heterotrimeric G proteins).
  
  These unique antibodies do not recognize the inactive (GDP bound) G proteins.
  
  These monoclonal antibodies have been successfully used to immunoprecipitate active G proteins from cell lysates, and for immunohistochemical staining of active G proteins in cultured cells or in tissue sections.
  
  Hence, these antibodies can be used to study the spatial and temporal dynamics of cellular signaling involving big and small G proteins, the future direction of signal transduction studies.