Chlorogenic Acid Metabolism Caffeic Administration - China

Chlorogenic Acid Original Plant Is the dried flower bud or

opening flower of Lonicera japonica Thunb., Lonicera hypoglauca Miq.,

Lonicera confusa DC.

or Lonicera dasystyla Rehd.

(Fam.

Caprifoliaceae).

Specification 4%-99%

Chemical Name 3-O-caffeoylquinic acid

Test Method HPLC

Molecular Formula C16H18O9

Molecular Weight 354.31

CAS No.

327-97-9

EINECS No.

206-325-6

Melting Point 205-209°C

Solubility Good solubility in water, easy soluble in hot water, ethanol, acetone, hard soluble in ethyl acetate.

Pharmacology Action: Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee, but is also found widespread in plants and can be isolated from the leaves and fruit This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.

This acid is an important factor in plant metabolism.

It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters; at concentrations as high as 100 µg/L, does not inhibit the 5-lipoxygenase activity of ionophore-stimulated human polymorphonuclear leukocytes.

Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of Type 2 Diabetes Mellitus and cardiovascular disease .

Chlorogenic acid is an important factor in plant metabolism.

It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters.

Chlorogenic acid, at concentrations as high as 100 um, does not inhibit the 5-lipoxygenase activity of ionophore-stimulated human polymorphonuclear leukocytes.

Chlorogenic acid, daily intake in coffee drinkers is 0.5–1g.

Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of cardiovascular disease.

Chlorogenic acid has been proven in animal studies in vitro to inhibit the hydrolysis of the glucose-6-phosphate enzyme in an irreversible fashion.

This mechanism allows chlorogenic acid to reduce hepatic glycogenolysis (transformation of glycogen into glucose) and to reduce the absorption of new glucose.

In addition, in vivo studies on animal subjects have demonstrated that the administration of chlorogenic acid lessens the hyperglycemic peak resulting from the glycogenolysis brought about by the administering of glucagen, a hyperglycemiant hormone.

The studies also confirmed a reduction in blood glucose levels and an increase in the intrahepatic concentrations of glucose-6-phosphate and of glycogen.

Chlorogenic acid can be used as anti-infectious active ingredient, it has wide anti-virus, anti-bacteria effects, and has relatively lower toxicity and side-effects.

It has obvious anti-infectious effects, and does not like to lead Anti-microbial Resistance.

Due to its obvious anti-infectious effects, it not only can be used in pharmaceutical field but can be used widely in many other fields like food, feed additives, cosmetics also.

Chlorogenic Acid

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Company Contact:

• Posted By: Changsha Huir Biological-Tech Co.,Ltd,

• Phone: 8613675901168

• Address: Rm 2002, jindan Building, No.1 Xiongtian Rd, Longp, changsha , China

• Email:

• Website: http://www.phyhuir.com

• Business Description: Changsha Huir (CSHR) has been dedicated to the research and development of herbal and nutraceutical ingredients since 1997 - for the past 10years , We strictly control the quality from raw material to the finished product, and make our spirits of pursuing perfect embody in our herbal extract products field.
  
  CSHR is a professional manufacture and develope of high quality and standard botanical extracts for human health come from nature.
  
  At present, Our company has adopted internationally first tare manufacturing facilities and technology and is based on the strong R&D capability.
  
  Therefore the enterprise has core competencies, Now our factory had three first class muti functional production assembly, they were used to purify plant , and the assembiles are most advanced both at home and abroad.
  
  And we also had high technicals force, complete detection means, and can be engaged in drawign and processing of investor's raw material business of many kinds of plants, Main products are : Ginseng P.
  
  E, Gotu Kola, Linseed Powdered Extract, Angelica Extract Powder, Aloe Vera, Echinacea Extract Powder, Epimedium Extract Powder, Red Clover Extract Powder, Valerian, Punica Granatum L., Ginkgo Biloba and so on, it sells to be 100% by export usually.
  
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