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  • Methyl Cinnamic Acid Ester C11h12o2 White To Light Yellow Crystalline Powder - China

    price: 1.00 Dollar US$

    4-methyl cinnamic acid methyl ester is a pharmaceutical intermediate.

    It is mainly used for the synthesis of methyl bromomethylcinnamate, the upstream raw material of the antithrombotic drug Ozagrel sodium.

    Methyl p-methylcinnamate is brominated by N-bromosuccinimide to obtain methyl p-bromomethylcinnamate, methyl p-bromomethylcinnamate in ionic liquid N-n-butylpyridine tetrafluoroboron The acid salt was lyophilized with imidazole at room temperature and then hydrolyzed to obtain an antithrombotic drug, ozagrel sodium, with a total yield of 67%.

    Methyl p-methylcinnamate is first reacted with p-methylbenzaldehyde and malonic acid to form p-methylcinnamic acid, which is then esterified with p-methylcinnamic acid and methanol to form methyl p-methylcinnamate.

    The process for preparing cinnamate by condensation of benzoquinone with acetate is known as the Claisen-Schmidt condensation reaction.

    The main methods for preparing cinnamate by Claisen-Schmidt reaction are as follows:

    1 - Prepared with anhydrous ethanol as solvent and 10% NaOH as catalyst, but the method has long reaction time and side reaction.

    Should be more, product yield is low, production efficiency is poor.

    2 - The acetic acid ester is used as a solvent and the sodium alkoxide is used as a catalyst to condense.

    This method improves the product yield, but the post-treatment is complicated and the purification is difficult.

    In the preparation, a large excess of the raw material ratio of the acetate is used, and the excess acetate is prone to ester condensation reaction under a strong basic catalyst, and a large amount of by-products are formed, which leads to difficulty in product purification.

    In addition, methyl methyl cinnamate is mostly obtained by reacting p-methylbenzaldehyde with acetic anhydride or malonic acid to obtain p-methylcinnamic acid, followed by esterification with methanol to obtain methyl p-methylcinnamate.

    Synthetic method.

    Because of the existing process steps, poor production conditions, low product yield, high cost and serious pollution, it does not meet the requirements of green production.


    Company Contact:


    • Phone: +8615071250651

    • Address: Tazi E. Road, No.18 Jiangan District, Wuhan City, Hubei Province, China

    • Email: Email


    Published date: November 20, 2019

    • Business Description: Product Rangeļ¼š Cinnamic alcohol, Cinnamaldehyde, Trans Cinnamic acid, Methyl cinnamate, Ethyl cinnamate

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