Methyl Cinnamic Acid Ester C11h12o2 White To Light Yellow Crystalline Powder - China
price: 1.00 Dollar US$
4-methyl cinnamic acid methyl ester is a pharmaceutical intermediate.
It is mainly used for the synthesis of methyl bromomethylcinnamate, the upstream raw material of the antithrombotic drug Ozagrel sodium.
Methyl p-methylcinnamate is brominated by N-bromosuccinimide to obtain methyl p-bromomethylcinnamate, methyl p-bromomethylcinnamate in ionic liquid N-n-butylpyridine tetrafluoroboron The acid salt was lyophilized with imidazole at room temperature and then hydrolyzed to obtain an antithrombotic drug, ozagrel sodium, with a total yield of 67%.
Methyl p-methylcinnamate is first reacted with p-methylbenzaldehyde and malonic acid to form p-methylcinnamic acid, which is then esterified with p-methylcinnamic acid and methanol to form methyl p-methylcinnamate.
The process for preparing cinnamate by condensation of benzoquinone with acetate is known as the Claisen-Schmidt condensation reaction.
The main methods for preparing cinnamate by Claisen-Schmidt reaction are as follows:
1 - Prepared with anhydrous ethanol as solvent and 10% NaOH as catalyst, but the method has long reaction time and side reaction.
Should be more, product yield is low, production efficiency is poor.
2 - The acetic acid ester is used as a solvent and the sodium alkoxide is used as a catalyst to condense.
This method improves the product yield, but the post-treatment is complicated and the purification is difficult.
In the preparation, a large excess of the raw material ratio of the acetate is used, and the excess acetate is prone to ester condensation reaction under a strong basic catalyst, and a large amount of by-products are formed, which leads to difficulty in product purification.
In addition, methyl methyl cinnamate is mostly obtained by reacting p-methylbenzaldehyde with acetic anhydride or malonic acid to obtain p-methylcinnamic acid, followed by esterification with methanol to obtain methyl p-methylcinnamate.
Synthetic method.
Because of the existing process steps, poor production conditions, low product yield, high cost and serious pollution, it does not meet the requirements of green production.
Company Contact:
- Posted By: Wuhan LANDMARK Industrial Co., Ltd
- Phone: +8615071250651
- Address: Tazi E. Road, No.18 Jiangan District, Wuhan City, Hubei Province, China
- Email:
- Website: https://www.landmarkind.com
Published date: November 20, 2019
- Business Description: Product Rangeļ¼ Cinnamic alcohol, Cinnamaldehyde, Trans Cinnamic acid, Methyl cinnamate, Ethyl cinnamate
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